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icosapentaenoate biosynthesis II (6-desaturase, mammals)

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
linolenic_acid + ATP + CoA <=> linolenoyl-CoA + diphosphate + AMP 1.13.12.7 firefly luciferase
6.2.1.2 medium-chain acyl-CoA ligase
6.2.1.3 long-chain-fatty-acid---CoA ligase



(3R,8Z,11Z,14Z,17Z)-3-hydroxyicosatetraenoyl-CoA <=> (2E,8Z,11Z,14Z,17Z)-icosapentaenoyl-CoA + H2O 4.2.1.134 very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase

linolenoyl-CoA + O2 + ferricytochrome_b5 + H+ <=> stearidonoyl-CoA + H2O + ferricytochrome_b5 1.14.19.3 acyl-CoA 6-desaturase

(8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-CoA + O2 + ferricytochrome_b5 + H+ <=> eicosapentaenoyl-CoA + H2O + ferricytochrome_b5 1.14.19.44 acyl-CoA (8-3)-desaturase

(8Z,11Z,14Z,17Z)-3-oxoicosatetraenoyl-CoA + NADPH + H+ <=> (3R,8Z,11Z,14Z,17Z)-3-hydroxyicosatetraenoyl-CoA + NADP+ 1.1.1.330 very-long-chain 3-oxoacyl-CoA reductase

malonyl-CoA + stearidonoyl-CoA + H+ <=> (8Z,11Z,14Z,17Z)-3-oxoicosatetraenoyl-CoA + CoA + CO2 2.3.1

(2E,8Z,11Z,14Z,17Z)-icosapentaenoyl-CoA + reduced_acceptor <=> (8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-CoA + acceptor 1.3.1.93 very-long-chain enoyl-CoA reductase

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